Prof Suresh Sundram: Schizophrenia, clozapine and molecular biology

Professor Suresh Sundram asks what is the actual molecular biology underlying the pathology of #schizophrenia? 2:00 Schizophrenia has heterogeneous symptoms (grouped approximately into Psychosis, Deficit Syndrome, Cognition and ’Other’ including suicidality). Only psychosis has any treatments. 7:29 Clozapine has anti-psychotic effects mediated through the epidermal growth factor (EGF) receptor! 12:40 EGF reduced in schizophrenia but not other psychotic disorders. 15:07 Clinical study to translate these findings into biomarkers. They found that about 50% of patients responded to clozapine. 19:47 Conclusion See more videos from the 2015 Monash Translational Research Symposium at: More about A/Prof Suresh Sundram: