LSD Synthesis in 7 Steps (Educational) | Lysergic acid, organic chemistry, reaction mechanisms

This video does not explain or suggest how to make drugs, and is purely educational and theoretical. A team of chemists recently reported a synthesis of lysergic acid, the precursor of the psychoactive drug LSD, in only 6 laboratory steps. In this video, we will learn why LSD-like scaffolds are of interest to modern drug discovery and look into the chemistry of this short but sweet synthesis. Please drop a like and comment to support the video’s visibility, activate notifications and subscribe to the channel so you do not miss future videos! Reference: - Six-Step Synthesis of (±)-Lysergic Acid; - Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure–Activity Relationship Studies; 00:00 Why science cares about LSD (lysergic acid diethylamide) 02:11 High-level retrosynthesis of lysergic acid 03:13 Forward synthesis of lysergic acid 06:14 Broader application to pharmaceutically relevant structures Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world’s most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)