The Proteasome (2024) by Etsuko Uno

This Proteasome is a large enzyme complex that breaks down old or damaged proteins into smaller pieces for cellular maintenance and recycling. Created with structural data from X-ray crystallography and cryo-electron microscopy, this animation provides a detailed visualization of the proteasome’s molecular machinery. Presented here are critical steps of protein degredation including ubiquitin tagging, unfolding by the regulatory particle, and proteolytic degradation within the core particle. Featured structures include 6MSB, 6MSD, 6MSE, 6MSG, 6MSH, 6MSJ, 6MSK, 5LE5, 2KDE, 2KR0, 6FVW, 5L4K, 6U19. All can be found at RSCB Protein Data Bank ().