Ivermectin and Cancers

Ivermectin, a potential anticancer drug derived from an antiparasitic drug Mechanisms of action IVM induces different programmed cell death patterns in different tumor cells, the main form of IVM induced programmed cell death is apoptosis. Apoptosis Programmed cell death Autophagy Lysosomal-dependent form of programmed cell death. Pyroptosis Inflammatory cell death induced by inflammasomes. Kathleen T Ruddy, MD Forms of cancer Breast cancer A malignant tumor produced by gene mutation in breast epithelial cells Digestive system cancer Gastric cancer is one of the most common malignant tumors worldwide. Hepatocellular carcinoma is the fourth leading cause of cancer death worldwide. Urinary system cancer Renal cell carcinoma is a fatal malignant tumor of the urinary system derived from renal tubular epithelial cells. Prostate cancer is a malignant tumor derived from prostate epithelial cells Hematological cancer Leukemia is a type of malignant clonal disease caused by abnormal hematopoietic stem cells Reproductive system cancer Cervical cancer is one of the most common gynecological malignancies Ovarian cancer is a malignant cancer that lacks early clinical symptoms and has a poor therapeutic response. Brain glioma Glioma is the most common cerebral tumor Glioblastoma, median survival time of 14-17 months Respiratory system cancer Nasopharyngeal carcinoma is a malignant tumor derived from epithelial cells of the nasopharyngeal mucosa. Lung cancer has the highest morbidity and mortality among cancers Melanoma The most common malignant skin tumor with a high mortality rate. Other papers Ivermectin suppresses tumour growth and metastasis through degradation of PAK1 in oesophageal squamous cell carcinoma Antitumor effects of ivermectin at clinically feasible concentrations support its clinical development as a repositioned cancer drug Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer Abstract 2320: Ivermectin suppresses pancreatic cancer via mitochondria dysfunction Video reviews @