The Hardy–Weinberg principle relates allele frequencies to genotype frequencies in a randomly mating population. Imagine that you have a population with two alleles (A and B) that segregate at a single locus. The frequency of allele A is denoted by p and the frequency of allele B is denoted by q. The Hardy–Weinberg principle states that after one generation of random mating genotype frequencies will be p2, 2pq, and q2. In the absence of other evolutionary forces (such as natural selection), genotype frequencies are expected to remain constant and the population is said to be at Hardy–Weinberg equilibrium. The Hardy–Weinberg principle relies on a number of assumptions: (1) random mating (i.e, population structure is absent and matings occur in proportion to genotype frequencies), (2) the absence of natural selection, (3) a very large population size (i.e., genetic drift is negligible), (4) no gene flow or migration, (5) no mutation, and (6) the locus is autosomal. When these assumptions are violated, departures from Hardy–Weinberg proportions can result.
One useful way to think about the Hardy–Weinberg principle is to use the metaphor of a gene pool (Crow, 2001). Here, individuals contribute alleles to an infinitely large pool of gametes. In a randomly mating population without natural selection, offspring genotypes are found by randomly sampling two alleles from this gene pool (one from their mother and one from their father). Because the allele that an individual receives from their mother is independent of the allele they receive from their father, the probability of observing a particular genotype is found by multiplying maternal and paternal allele frequencies. Mathematically this involves the binomial expansion: (p q)2 = p2 2pq q2 (see the modified Punnett Square in Figure 1 for a graphical representation). Note that there are two ways that an individual can be an AB heterozygote: they can either inherit an A allele from their mother and a B allele from their father or they can inherit a B allele from their mother and an A allele from their father.
#HardyWeinbergPrinciple #MathematicsFieldOfStudy #genetics #AlleleFrequency #HardyWeinbergLaw #population #alleleFrequencies #mutation #genotypes #HardyWeinbergEquilibrium #populationGenetics #hardyWeinbergAssumptions #hardyWeinberg #genotypeFrequencies #hardyWeinbergEquations #hardyWeinbergEquilibriumExplained #genotype #educational #biology #NikolaysGeneticsLessons #apBiology #hardyweinbergProblems #hardyWeinbergEquilibrium #genes
1 view
117
33
2 weeks ago 00:09:25 1
Boss RC-505 Loop Station - Multi-Instrumental Live Looping - Reinhardt Buhr
2 weeks ago 00:04:43 1
The Producers - Springtime for Hitler
2 weeks ago 00:02:34 1
Pretty in Pink A Timeless Tale of Love and Social Struggle 1986
2 weeks ago 00:00:30 1
Karpatka recipe / Karpatka
2 weeks ago 00:00:20 1
Smallest Black Hole meets The RED GIANT 💀
2 weeks ago 00:02:21 1
THE TEXAS CHAINSAW MASSACRE: THE GAME | Rush Week Trailer (2024)
2 weeks ago 00:03:44 16
[Dua Lipa] Dua Lipa - New Rules (Official Music Video)
2 weeks ago 00:23:11 1
Digraphs | ch, sh, th, ck, ph, gh, wh | Rock ’N Learn Phonics Songs
2 weeks ago 00:00:47 1
Cole Palmer picks between the two GOATs in football knockout 🐐
2 weeks ago 00:01:53 1
Sofia Coppola on finding professional and personal fulfillment
2 weeks ago 00:08:39 1
Metallica: 72 Seasons (Official Music Video)
2 weeks ago 00:02:38 1
Dozens killed in Beirut attack, including three children and seven women
2 weeks ago 00:03:14 1
Kaeyra - Sour [Official Music Video]
2 weeks ago 01:03:17 1
Selected Sessions MK b2b Sonny Fodera U-Bahn DJ Set
2 weeks ago 00:04:01 1
Ed Sheeran - Bad Habits [Official Video]
2 weeks ago 00:09:06 1
Vs. Leads Sniper | Which is the best Google Maps Scraper? 💯
2 weeks ago 00:03:12 1
Two Feet - Think I’m Crazy (Unplugged) [Official Audio]
2 weeks ago 00:05:34 1
Madonna - Hung Up (Official Video) [HD]
2 weeks ago 00:00:31 1
Welcome to Sexplanations
2 weeks ago 00:26:15 1
Sofia Coppola interview on “Lost in Translation“ (2003)
2 weeks ago 00:12:08 1
Two Steps From Hell - Star Sky ( EXTENDED Remix by Kiko10061980 )