Beautiful imaging of zebrafish development

Fluorescence light sheet microscopy is a powerful tool to image developmental processes in vivo, but it is limited by the inability to image structures beyond the labelled tissue. In their paper in Development, an Italian-German team (Andrea Bassi from Milan, Benjamin Schmid and Jan Huisken from Dresden) overcome this limitation by combining optical tomography with selective plane illumination microscopy (SPIM). The applications of this approach to the study of organogenesis are obvious in this video. It sh