AlphaFold: The making of a scientific breakthrough

The inside story of the DeepMind team of scientists and engineers who created AlphaFold, an AI system that is recognised as a solution to “protein folding“, a grand scientific challenge for more than 50 years. Find out more: Protein references: TBP = To be published 1BYI: Sandalova, T., et al. (1999) Structure of dethiobiotin synthetase at A resolution. Acta Crystallographica Section D 55: 610-624. 3NPD: Das, D. et al. (2014) Crystal structure of a putative quorum sensing-regulated protein (PA3611) from the Pseudomonas-specific DUF4146 family. Proteins 82: 1086-1092. 5AOZ: Bule, P., et al. Structural Characterization of the Third Cohesin from Ruminococcus Flavefaciens Scaffoldin Protein, Scab. (TBP) 5ERE: Joachimiak, A. A novel extracellular ligand receptor. (TBP) 5L8E: Dharadhar, S., et al. (2016) A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme. Journal of Structural Biology 196: 437-447.