Medical Animation: Heart Failure (HFrEF)

3D Medical animation about decreased contractility in heart failure (HFrEF) for professional education and to highlight the unmet need for treatments that directly increase contractility. We created a novel scientific visualization of sarcomere mechanics, showing the complex steps of the actin-myosin crossbridge cycle in detail. The molecular models and animation are data-driven. We made a conscious design decision to adjust the sarcomere’s scale and speed to provide a clearer view of its function. The video has been used globally by three partnered pharmaceutical companies to increase awareness among clinicians. The medical communications sponsor deployed it to heart congresses (virtual and in-person), presentations, face-to-face meetings and as an online educational resource, calling the video “one of the most popular assets for our disease state education campaign.” It went on to win the Award of Excellence in Instructional Animation at the 2020 Association of Medical Illustrators annual meeting. Scien