The Science Behind Why We Age | Lifespan with Dr. David Sinclair #1
In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of “ex-differentiation“ in which cells begin to lose their identity, and how all of this makes up the “Information Theory of Aging“, and the difference between “biological age“ and “chronological age“ and how we can measure biological age through DNA methylation clocks.
#Aging #DavidSinclair #Longevity
Thank you to our sponsors:
Athletic Greens -
InsideTracker -
Levels -
Our Patreon page:
Lifespan book:
Dr. David Sinclair Social:
Instagram -
Twitter -
Facebook -
Matthew LaPlante’s Social:
Twitter -
Timestamps:
00:00:00 Introduction
00:03:14 Goal of the Lifespan Podcast
00:07:11 Acknowledgement of Sponsors
00:10:45 Aging is a Controllable Process that can be Slowed & Reversed
00:16:42 Organisms with Extreme Longevity
00:21:47 Genes that Regulate Aging: mTOR, AMPK, Sirtuins
00:21:55 mTOR & Rapamycin
00:24:33 AMP-activated protein kinase (AMPK) & Metformin
00:30:57 Sirtuin Proteins as Epigenetic Regulators of Aging
00:35:33 Ex-Differentiation
00:43:30 Measuring Aging - Biological Age vs. Chronological Age
00:49:30 “No Law That Says We Have To Age“
00:50:33 Episode Summary & Key Takeaways - Why Do We Age?
00:54:00 Information Theory of Aging
00:57:59 Aging is a Medical Condition
01:01:00 Aging Myths - Telomeres & Antioxidants
01:01:55 Options for Subscription and Support
Links:
Weapon fragments in bowhead whales -
Rapamycin extends lifespan in mice -
Targeting Aging with Metformin (TAME) Trial -
Metformin improves healthspan and lifespan in mice -
Metformin reduces all-cause mortality -
Reprogramming to restore vision -
DNA methylation age -
Genome-wide methylation profiles & human aging rates -
Reversal of epigenetic aging in humans -
Danish twins study -
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair’s teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.
1 view
569
177
4 months ago 00:04:52 1
Сказка “Война грибов“
4 months ago 00:01:06 1
X2.9 flare! Sunspot AR3664 returns with major eruption, spits fire
4 months ago 00:00:21 2
How To Save A Cow That Is Bloated (@ToddFamilyFarm)
4 months ago 00:22:05 1
Le Journal Secret de l’Amiral Byrd - La Terre Creuse ? 🎙
4 months ago 02:34:25 1
#1099 Андрей Тархов: Делаются большие ставка на биоинформатику, но ’позволит’ ли нам AI жить дольше?
4 months ago 00:25:35 1
Падение элит
4 months ago 00:04:32 1
Emperor penguin chicks jump off a 50-foot cliff in Antarctica NEVER-BEFORE-FILMED FOR TV | Nat Geo
4 months ago 00:04:13 1
“qu’est ce que la matrice ? “ extrait de Matrix des Wachowski (1999)
4 months ago 00:01:17 1
CEERS: Flight to Maisie’s Galaxy
4 months ago 00:24:04 1
ЗУБЫ. Что это такое и какими они бывают.
4 months ago 00:06:33 1
Что происходит с ТВОИМ ТЕЛОМ при курении? — Научпок
4 months ago 00:03:26 1
New Phones 2025 — Samsung Galaxy S25 Ultra — NEW Massive Camera Specs & Leaks
4 months ago 00:24:25 1
NASA’s Newly Released Images Of MARS #10 (2024)
4 months ago 01:19:56 1
Climate: The Movie (The Cold Truth) English
4 months ago 00:13:38 1
Топ-7 продуктов для детоксикации печени💥
4 months ago 00:14:47 1
4/20/2015 -- EU building FIVE new “HAARP type“ arrays -- 50,000 antennas called EISCAT 3D
4 months ago 00:08:10 2
The Space Shuttle’s Luckiest Escape
4 months ago 00:00:11 1
Testing tiger beetles’ palatability to bats
4 months ago 00:06:42 1
Телегония. Очередной капкан от (((науки))) // Марко Бондаренко
4 months ago 00:10:43 1
Пейте это каждый день и катаракты не будет 🙌
4 months ago 00:15:59 1
Не смотрите это видео! После него вы не сможете есть сахар!👀
4 months ago 00:01:18 1
360 Video: NASA Simulation Shows a Flight Around a Black Hole
4 months ago 00:06:00 1
Домашняя зубная паста от зубного камня 👉 лучшее средство