Toxicology of Acetylcholinesterase Inhibitors (I) - Neurotransmission

Short video (Part I of the 3 part series) illustrating the cholinergic neurotransmission. The issue of the nerve agent VX, was recently raised publicly. VX is a very potent organophosphate inhibitor of acetylcholinesterase. Acetylcholinesterase is a very important enzyme that hydrolyses acetylcholine in the synaptic clefts of cholinergic neurones. By so doing, it is able to terminate neuronal transmission. Acetylcholinesterase inhibitors prevent degradation of acetylcholine, and leads to an excess of choli